The high level of creatinine, a creatine derivative, in a patient undergoing COVID-19 is a factor in poor prognosis and increases the risk of death, according to a study by Spanish scientists.
According to the research team of the hospital in Tomelloso, in central Spain, higher-than-normal levels of creatinine in the body increase the probability of death from coronavirus infection several times.
The authors of the study, which analyzed nearly 500 cases of adult COVID-19 patients hospitalized in the spring of 2020, explained that their study included various cases of people with COVID-19, including suffering from chronic diseases.
The study, published in the scientific journal Journal of Clinical Medicine, proves that serum creatinine analysis should be one of the main elements in determining the prognosis of a patient with COVID-19.
Dr. Modesto Maestre, who participated in the study, explained that the level of creatinine is as important a factor in examining the patient's chances of survival as his age or the fact that he or she has chronic respiratory or circulatory system diseases.
He noted that a high level of creatinine is a premise for poor prognosis for a patient with COVID-19. He added that this element is more important than factors such as diabetes in the patient, obesity or immunosuppression.
Maestre indicated that a 1 mg/dl increase in serum creatinine concentration could increase the risk of death in a patient infected with coronavirus by three times.
Creatinine is an organic chemical compound, creatine derivative found in blood and urine, a product of metabolism. It is excreted from the body through the kidneys in the urine. In diagnostics, creatinine is one of the biochemical markers that allow monitoring the condition of the kidneys. Its level is also controlled, among others to check whether the patient can be given the contrast used during computed tomography or magnetic resonance imaging (PAP).
Author: Marcin Zatyka