Studies in mice have shown that high levels of the SIRT6 protein can extend life by an average of 30 percent. In the case of humans, this would mean that a 90-year-old person could live to be 120 years old, reports Nature Communications.
A team of researchers from the National Institutes of Health in the USA, the Institute of Biomedical Research in Barcelona and the Israeli Institute of Technology focused on the action of the SIRT6 protein, which is involved in the regulation of many biological processes, such as aging, obesity and insulin resistance.
It was observed that transgenic mice with high levels of the SIRT6 protein lived by 30 percent. longer than the control group. This applied to both females and males. Moreover, these mice coped better with many diseases of the old age, such as cancer and blood diseases, and showed the same level of activity as young animals and were not susceptible to so-called. weakness syndrome.
Then, as a result of a series of biochemical studies, scientists were able to elaborate the mechanism of the rejuvenating action of SIRT6. It has been found that older animals lose their ability to generate energy when it is lacking from external sources. In the case of transgenic mice, however, this ability was maintained thanks to the use of, among others from the breakdown of fats and lactic acid. In this way, energy was delivered to the muscles and the brain.
Many studies show that healthy aging is largely dependent on diet and metabolism. White SIRT6 promotes longevity by activating analogous processes. If we can determine how to activate these processes in humans, we will be able to develop methods conducive to a long and healthy life, "the authors write. (PAP)